Skyrim without a doubt, cannot wait. I was really disappointed with the Wiiu, it looks too similar to the current Wii and the new controller looks very 'gimmicky'.
TrackMania 2, only because that's one of the few games I play and I don't have any interest in buying a game system or spending a whole lot of money on games.
Skyrim looked good, also interested in Battlefield. Then there's the Call of Duty 4, (may be more of the same, but it still looked good). Also liked SSX, (would be a nice change from shooters).
Saw the demo of Twisted Metal and was very impressed, unfortunately I don't have a PS3. I don't know what to think of Mass Effect 3, (still have not played 1 or 2 so I can't really say).